Methods for Translational Behavioral Research (2014 NIH Workshop)
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Specific Aims: The National Institutes of Health sponsored a cross-institute, two-day "Workshop on Innovative Study Designs and Methods for Developing, Testing and Implementing Behavioral Interventions to Improve Health" to review, evaluate, and disseminate a selection of innovative designs and analytic strategies for use in behavioral intervention studies. Experts from the behavioral, biostatistical and clinical communities reviewed the utility of new, innovative and potentially more efficient study designs and methods to develop, optimize, test and implement behavioral interventions across the translational targeting multiple behavioral risk factors (e.g., adherence, diet, physical activity, smoking). Presentations and discussions focused mainly on the development and preliminary testing of behavioral interventions on Day 1, with an emphasis on later-stages of development, including testing and implementation of interventions within clinical and community contexts, on Day 2.
COLLECTIONS:
Day 1 (April 2, 2014)
8:15am
NHLBI Perspective: The Need for Creative New Methods in Clinical Research
Speaker: Michael Lauer, M.D., Director, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute
Key Articles
8:45 AM
Developing and Optimizing Behavioral Treatments to Prevent and Treat Disease
Susan Czajkowski, Ph.D., National Heart, Lung, and Blood Institute
9:00 AM
Panel 1: Novel techniques for defining the intervention and its targets
Moderator: Christine Hunter, Ph.D., National Institute of Diabetes and Digestive and Kidney Diseases
Behavioral Event Modeling: Identifying and utilizing key inflection points to promote health behavior change - Brian Wansink, Ph.D., Cornell University
Analyzing patient-provider communication in clinical contexts to identify novel behavior change targets - April Carcone, Ph.D., Wayne State University
Key Articles
- Hybrid Insights: Where the Quantitative Meets the Qualitative
- Behavioral Event Modeling: Identifying and utilizing key inflection points to promote health behavior change
- Leveraging Inside Sources of Consumer Insights
- Analyzing patient-provider communication in clinical contexts to identify novel behavior change targets
- Analysis of Behavioral Streams
10:50 AM
Panel 2: Intervention Development and Preliminary Testing: Within-subjects and Small-N Studies
Moderator: Stacey FitzSimmons, Ph.D., Center for Scientific Review
Single-case experimental designs- Bethany Raiff, Ph.D., Rowan University
Modeling individual trajectories: Subject specific coding for population parameter estimates of treatment effects- Thomas Templin, Ph.D., Wayne State University
Three techniques for rigorous analysis of intensive within-person experiments- Ty Ridenour, Ph.D., Research Triangle Institute
Key Articles
- Single-Case Experimental Designs to Evaluate Novel Technology-Based Health Interventions
- Optimizing behavioral health interventions with single-case designs: from development to dissemination
- Analyzing Data from Single-Case Designs Using Multilevel Models: New Applications and Some Agenda Items for Future Research
- Toward Rigorous Idiographic Research in Prevention Science: Comparison between Three Analytic Strategies for Testing Preventive Intervention in Very Small Samples
1:20 PM
Panel 3: Study Designs for Refining, Tailoring and Optimizing Interventions I
Moderator: Laura Lee Johnson, Ph.D., National Center for Complementary and Alternative Medicine
The Multiphase Optimization Strategy (MOST): A new approach to building effective and efficient behavioral interventions- Kari Kugler, Ph.D., The Pennsylvania State University
Bayesian estimation for dose-finding studies - Yuan Ji, Ph.D., University of Chicago
Key Articles
2:50 PM
Panel 4: Study Designs for Refining, Tailoring and Optimizing Interventions II
Moderator: William Riley, Ph.D., National Cancer Institute
Adaptive Interventions: From SMART to Just-in-Time Adaptive Interventions (JITAI)- Inbal (Billie) Nahum-Shani, Ph.D., University of Michigan
Designing user-centered just-in-time adaptive interventions- Pedja Klasnja, Ph.D., University of Michigan
Personalizing Behavioral Interventions using Mobile Sensing- Tanzeem Choudhury, Ph.D., Cornell University
Application of JITAI to substance abuse research- David Gustafson, Ph.D., Univer of Wisconsin at Madison
Key Articles
- Experimental Design and Primary Data Analysis Methods for Comparing Adaptive Interventions
- Q-Learning: A Data Analysis Method for Constructing Adaptive Interventions
- A “SMART” Design for Building Individualized Treatment Sequences
- Designing user-centered just-in-time adaptive interventions- Pedja Klasnja, Ph.D., University of Michigan
- Tracking Mental Well-Being: Balancing Rich Sensing and Patient Needs
- A Smartphone Application to Support Recovery From Alcoholism -A Randomized Clinical Trial
4:40 PM
Developing and Optimizing Behavioral Interventions: Commentary and Additional Considerations
Moderator: Robert Kaplan, Ph.D., Director, NIH Office of Behavioral and Social Sciences Research
Speakers:
- Mario Stylianou, Ph.D, National Heart, Lung, and Blood Institute
- Bonnie Spring, Ph.D., Northwestern University
Key Articles
- Advances in and Limitations of Up-and-down Methodology: A Précis of Clinical Use, Study Design, and Dose Estimation in Anesthesia Research
- Multiple Behavior Changes in Diet and Activity: A Randomized Controlled Trial Using Mobile Technology
- Integrating Technology into Standard Weight Loss Treatment: A Randomized Controlled Trial
Day 2 (April 3, 2014)
8:15 AM
Summary of Day 1 and Introduction to Day 2
Speakers:
- Bonnie Spring, Ph.D., Northwestern University
- Sylvie Naar-King, Ph.D., Wayne State University
- Kate Stoney, Ph.D., National Heart, Lung, and Blood Institute
Key Articles
9:15 AM
Panel 5: Innovative Approaches to Improve the Reach, Delivery and Impact of Behavioral Interventions
The application of social network analysis to health behavior interventions- Douglas Luke, Ph.D., Washington University in St. Louis
Complex systems modeling for behavioral research- Ross Hammond, Ph.D., Brookings Institution
Harnessing “small data” for personalized health promotion - Deborah Estrin, Ph.D., Cornell NYC Tech
Moderator: Patricia Mabry, Ph.D., NIH Office of Disease Prevention
Key Articles
- Network Analysis in Public Health: History, Methods, and Applications
- Network Interventions
- Complex Systems Modeling for Obesity Research
- A systems science perspective and transdisciplinary models for food and nutrition security
- Making sense of mobile health data: An open architecture to improve individual and populate level health
- Viewpoint: small data, where n=me. Seeking personalized data-derived insights from analysis of our digital traces.
12:00 PM
Panel 6: Harnessing Existing Resources to Test and Implement Behavioral Interventions
Moderator: Wendy Weber, N.D., Ph.D., M.P.H., National Center for Complementary and Alternative Medicine
Conducting multifaceted behavioral pragmatic trials within integrated health care systems- Lynn DeBar, Ph.D., Kaiser Permanente Center for Health Research
Leveraging EHR’s in large simple trials of behavioral interventions- Elsie Taveras, M.D., Mass General Hospital for Children
Partnering with industry in the testing and implementation of behavioral interventions: Lessons from the Hopkins-Healthways collaboration- Janelle Coughlin, Ph.D., John Hopkins School of Medicine
Key Articles
- A primary care-based interdisciplinary team approach to the treatment of chronic pain utilizing a pragmatic clinical trials framework
- Provider Perspectives on Electronic Decision Supports for Obesity Prevention
- Rationale and design of the STAR randomized controlled trial to accelerate adoption of childhood obesity comparative effectiveness research
- Comparative Effectiveness of Weight-Loss Interventions in Clinical Practice
1:30 PM
Testing and Implementing Behavioral Interventions: Commentary and Additional Considerations
Moderator: Peter Kaufmann, Ph.D., National Heart, Lung, and Blood Institute
Key Articles